Objective To understand the diagnostic significance of ischemia modified albumin(IMA) in the diagnosis of acute myocardial ischemia(AMI).Methods 48 patients with myocardial ischemia, 134 non-myocardial ischemia patients, and 30 healthy people were selected to detect serum ischemia modified albumin(IMA) by albumin cobalt binding assay(ACB).SPSS 13.0 software was used to analyze test results.Results ACB value of myocardial ischemia group was significantly lower than that of the non-myocardial ischemia group or the control group.IMA positive rate and number were higher than those of LDH, CK, CK-MB, MB in this patient group.Conclusions Ischemia modified albumin is a early, sensitive and specific biochemical indicator for the judgment of acute myocardial ischemia.