Human rhinovirus( HRV) is a kind of with highly infectious which is responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. There is currently no antiviral drug approved for the treatment of such infections. Nevertheless,with the depth study of pathology rhinovirus,the process of rhinovirus infection was identified and a serious of antiviral compounds that inhibit the replication of the human rhinovirus were researched. As the clinical trials carry out,these molecules are expected to be the effective drugs for the treatment of rhinovirus in the future.