Changes of stearoyl coenzyme A desaturase in preschool children with obesity

Objective:To observe the changes of plasma monounsaturated fatty acids(MUFAs)level and activity of stearoyl coenzyme A desaturase(SCD),and explore their relationship with body mass index(BMI)in preschool children with obesity.Methods:36 obese children and 36 normal children aged 3～6 years old were selected according to 1∶1 pairing of gender and age.The composition of plasma fatty acids was detected by gas chromatographic analysis,the ratio of palmitoleic acid/palmitic acid(C16∶1n-7/C16∶0)represented the activity of SCD.Results:The total amounts of plasma palmitoleic acid,palmitic acid(C18∶1n-9)and MUFA and SCD activity in obese children were significantly higher than those in non-obese children(P0.05);correlative analysis showed that there was a positive correlation between SCD activity in obese children and BMI(P0.05).Conclusion:The increases of SCD activity and MUFAs level may play some roles in occurrence of obesity,but the specific mechanisms need to be clarified.