生物
外胚层
全能的
胚胎
母子转换
细胞生物学
胚泡
转录组
内胚层
卵裂球
原肠化
内细胞团
合子
遗传学
胚胎干细胞
计算生物学
胚胎发生
基因
基因表达
作者
Claire Chazaud,Yojiro Yamanaka
出处
期刊:Development
[The Company of Biologists]
日期:2016-04-01
卷期号:143 (7): 1063-1074
被引量:256
摘要
During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In recent years, studies have shown that this process appears to be regulated by differences in cell-cell interactions, gene expression and the microenvironment of individual cells, rather than the active partitioning of maternal determinants. Precisely how these differences first emerge and how they dictate subsequent molecular and cellular behaviours are key questions in the field. As we review here, recent advances in live imaging, computational modelling and single-cell transcriptome analyses are providing new insights into these questions.
科研通智能强力驱动
Strongly Powered by AbleSci AI