The research and progress of PI3K/Akt/mTOR signal transduction pathway in tumors

PI3K/Akt/mTOR signal transduction pathway is very important signal transduction pathway in mammalian cells,through its effect on the downstream effector molecules in the activated state,played in the intracellular inhibition of apoptosis,promoting proliferation. The new research shows that the PI3K/Akt/mTOR signal transduction pathway is closely related to liver cancer,colon cancer,lung cancer,breast cancer and other tumors occurrence and development,and PI3K/Akt/mTOR signal transduction pathways also plays an important role in tumor treatment. So I mad this atticle to comprehensive the PI3K/Akt/mTOR pathway components,molecular mechanism,function,and application in the aspects of in tumor treatment prospects research progress.