An Expedient Method for the Synthesis of Acylhydrazones under Microwave Irradiation in Solvent-free Medium

A simple, efficient and eco-friendly method for the synthesis of acylhydrazones from acylhydrazides and aldehydes under microwave (MW) irradiation was reported, no solvent and catalyst was used. The method is combined with a combinatorial approach and fourteen novel acylhydrazones were synthesized in excellent yields (89–96%) and short reaction times (less than 5 min).