Quantitative changes in serum IL-8, TNF-α and TGF-β1 levels depending on compensation stage in type 2 diabetic patients

Aim: To evaluate serum levels of cytokines, IL-8, TNF-α and TGF-β1, as well as HbA1c, total protein, albumin, urea, creatinine, IgG, IgA, IgM according to compensation stages in type 2 diabetic patients. Methods: All patients (n = 76), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation (n=28), subcompensation (n=20) and decompensation (n=28). Cytokines were measured by ELISA method. Control group included 20 healthy subjects. Results: Cytokine values increased in all three stages of the disease, especially in the stage of decompensation in comparison with control subjects. Conclusions: IL-8, TNF-α and TGF-β1 may participate in the development and progression of diabetic complications. Further study of these immune dates may open new perspective opportunities in prevention and treatment of late complications of diabetes.