Pharmaceutical Co-crystal: A New Paradigm for Enhancing the Physicochemical Properties of Active Pharmaceutical Ingredient

Pharmaceutical co-crystal consists of a stoichiometric ration of an Active Pharmaceutical Ingredient (API) and cocrystal former. Researcher from both Pharmaceutical industry and academic has great interest in designing of pharmaceutical co-crystal due to excellent enhancement of Physicochemical Properties of drug. This article focus on Cocrystal best solubility enhancement technique in comparison to other traditional technique, Definition of cocrystal and pharmaceutical cocrystal, Advantages of cocrystal in pharmaceutical industry, Design of pharmaceutical cocrystals, Physicochemical properties of cocrystals, Polymorphism in co-crystals, Mechanical properties improvement via cocrystallisation and finally Example of co-crystal.