Clinical features and molecular pathogenesis of hypervirulent Klebsiella pneumoniae

Rcently, a new hypervirulent and invasive variant of Klebsiella pneumoniae has emerged, whose defining clinical features were the ability to cause primary liver abscess, community-acquired pneumonia, endophthalmitis and metastatically spreading to other tissues with serious sequelae.Its enhanced virulence is closely related to the hypermucoviscous phenotype and the ability to acquire iron more efficiently.The clinical feature and molecular pathogensis of hypervirulent Klebsiella pneumoniae were discussed in this article, which had great significance to clinical treatment and further study. Key words: Klebsiella pneumoniae; Liver abscess; Hypermucoviscous; Aerobactin; Therapeutics