儿茶酚
分子
酪氨酸酶
化学
催化作用
酶
组合化学
小分子
共价键
材料科学
人工酶
纳米技术
有机化学
生物化学
作者
Qi‐Zhi Zhong,Joseph J. Richardson,Shiyao Li,Wenjie Zhang,Yi Ju,Jianhua Li,Shuaijun Pan,Jingqu Chen,Frank Caruso
标识
DOI:10.1002/anie.201913509
摘要
Abstract Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise for numerous applications. Universally adherent materials have recently emerged as versatile functional coatings; however, such coatings are generally limited to catechol, ( ortho ‐diphenol)‐containing molecules, as building blocks. Here, we report a facile, biofriendly enzyme‐mediated strategy for assembling a wide range of molecules (e.g., 14 representative molecules in this study) that do not natively have catechol moieties, including small molecules, peptides, and proteins, on various surfaces, while preserving the molecule's inherent function, such as catalysis (≈80 % retention of enzymatic activity for trypsin). Assembly is achieved by in situ conversion of monophenols into catechols via tyrosinase, where films form on surfaces via covalent and coordination cross‐linking. The resulting coatings are robust, functional (e.g., in protective coatings, biological imaging, and enzymatic catalysis), and versatile for diverse secondary surface‐confined reactions (e.g., biomineralization, metal ion chelation, and N ‐hydroxysuccinimide conjugation).
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