Manganese catalyzed C-alkylation of methyl N-heteroarenes with primary alcohols
小学(天文学)
药物化学
烷基
组合化学
作者
Akash Jana,Amol Kumar,Biplab Maji
出处
期刊:Chemical Communications [The Royal Society of Chemistry] 日期:2021-03-23卷期号:57 (24): 3026-3029被引量:6
标识
DOI:10.1039/d1cc00181g
摘要
C-Alkylations of nine different classes of methyl-substituted N-heteroarenes, including quinolines, quinoxalines, benzimidazoles, benzoxazoles, pyrazines, pyrimidines, pyridazines, pyridines, and triazines are disclosed. A bench stable earth-abundant Mn(i)-complex catalyzed the chemoselective hydrogen-transfer reaction utilizing a diverse range of primary alcohols as the non-fossil fuel-derived carbon source. The diversified N-heteroarenes (41 examples) were isolated in high yields and selectivities. Water is produced as the sole byproduct, making the protocol environmentally benign.