半合成
化学
组合化学
酿酒酵母
TRPC公司
块(置换群论)
计算生物学
生化工程
瞬时受体电位通道
立体化学
生物化学
受体
酵母
几何学
工程类
生物
数学
作者
Thomas Siemon,Zhangqian Wang,Guangkai Bian,Tobias Seitz,Ziling Ye,Yuchao Lu,Shu Cheng,Yunkun Ding,Yanglei Huang,Zixin Deng,Tiangang Liu,Mathias Christmann
摘要
Herein, we report a short semisynthesis of the potent transient receptor potential canonical (TRPC) channel agonist englerin A (EA) and the related guaianes oxyphyllol and orientalol E. The guaia-6,10(14)-diene starting material was systematically engineered in Escherichia coli and Saccharomyces cerevisiae using the CRISPR/Cas9 system and was produced with high titers. The potentially scalable approach combines the advantages of synthetic biology and chemical synthesis providing an efficient and economical method for producing EA and analogues.
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