冷凝集素病
医学
自身免疫性溶血性贫血
溶血
冷凝集素
补体系统
丝氨酸蛋白酶
经典补体途径
单克隆抗体
抗体
免疫学
蛋白酶
化学
生物化学
酶
作者
Alexander Röth,Wilma Barcellini,Shirley D’Sa,Yoshitaka Miyakawa,Catherine M. Broome,Marc Michel,David J. Kuter,Bernd Jilma,Tor Henrik Anderson Tvedt,Joachim Fruebis,Xiaoyu Jiang,Stella Lin,Caroline Reuter,Jaime Morales‐Arias,William E. Hobbs,Sigbjørn Berentsen
标识
DOI：10.1056/nejmoa2027760
摘要
In patients with cold agglutinin disease who received sutimlimab, selective upstream inhibition of activity in the classic complement pathway rapidly halted hemolysis, increased hemoglobin levels, and reduced fatigue. (Funded by Sanofi; CARDINAL ClinicalTrials.gov number, NCT03347396.).
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