Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021)

Linear and branched hydrocarbon chains may be appended or crosslinked at selected cysteine positions in unprotected peptides and proteins. The method involves nucleophilic substitution assisted by a simple zinc salt under mild conditions and can be applied at late stages of synthesis. More information can be found in the Full Paper by A. D. de Araujo, H. T. Nguyen, D. P. Fairlie.