磁共振成像
免疫疗法
免疫系统
生物医学中的光声成像
分子成像
正电子发射断层摄影术
荧光寿命成像显微镜
医学
医学影像学
材料科学
生物医学工程
放射科
免疫学
生物
荧光
体内
物理
生物技术
量子力学
光学
作者
Xianbin Ma,Mengjie Zhang,Jingting Wang,Ziqiang Tian,Peng Xue,Yuejun Kang,Zhi‐Jun Sun,Zhigang Xu
标识
DOI:10.1002/adma.202204034
摘要
Immunotherapy is one of the most promising clinical modalities for the treatment of malignant tumors and has shown excellent therapeutic outcomes in clinical settings. However, it continues to face several challenges, including long treatment cycles, high costs, immune-related adverse events, and low response rates. Thus, it is critical to predict the response rate to immunotherapy by using imaging technology in the preoperative and intraoperative. Here, the latest advances in nanosystem-based biomaterials used for predicting responses to immunotherapy via the imaging of immune cells and signaling molecules in the immune microenvironment are comprehensively summarized. Several imaging methods, such as fluorescence imaging, magnetic resonance imaging, positron emission tomography imaging, ultrasound imaging, and photoacoustic imaging, used in immune predictive imaging, are discussed to show the potential of nanosystems for distinguishing immunotherapy responders from nonresponders. Nanosystem-based biomaterials aided by various imaging technologies are expected to enable the effective prediction and diagnosis in cases of tumors, inflammation, and other public diseases.
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