奶油
神经科学
PI3K/AKT/mTOR通路
百里香科
蛋白激酶B
神经保护
记忆障碍
药理学
信号转导
医学
化学
生物
细胞生物学
生物化学
认知
转录因子
生态学
基因
作者
Yan Li,Yufan Jin,Pan Jiang,Xiang He,Shiqian Zhong,Rongcai Zhang,LokLam Choi,Weiwei Su,Jiaxu Chen
标识
DOI:10.1021/acs.jafc.2c02140
摘要
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is clinically characterized by the impairment of memory and cognition. Accumulation of β-amyloid (Aβ) in the brain is considered as a key process in the development of AD because it impairs the synapses' function to impair memory formation. Recent research studies have indicated that a group of edible plant-derived Thymelaeaceae compounds known as coumarin may exert particularly powerful actions on alleviating learning and memory impairment. 7,8-Dithydroxycoumarin (7,8-DHC), a bioactive component of coumarin derived from Thymelaeaceae, showed its function in neuroprotection before. In this study, we found that 7,8-DHC was able to mitigate Aβ accumulation via reducing the level of BACE1 and increasing the level of ADAM17 and ADAM10. More importantly, we found that 7,8-DHC could mitigate memory impairment, promote the dendrite branch density, and increase synaptic protein expression via activating PI3K-Akt-CREB-BDNF signaling. Hence, these results suggested that 7,8-DHC represented a novel bioactive therapeutic agent in mitigating Aβ deposition and synaptic loss in the process of treating AD.
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