生物膜
鲍曼不动杆菌
微生物学
铜绿假单胞菌
抗生素耐药性
抗药性
抗生素
生物
亚胺培南
PSL公司
细菌
人口
胞外聚合物
作者
Jing Wang,Xi Liu,Kaiwei Yu,Moxiao Liu,Jiuxin Qu,Yang Liu,Zhao Cai,Ke Wang,Chao Zhuo,Liang Yang,Yingdan Zhang
出处
期刊:ACS Infectious Diseases
[American Chemical Society]
日期:2021-12-22
标识
DOI:10.1021/acsinfecdis.1c00416
摘要
Co-infection of Pseudomonas aeruginosa (Pa) and Acinetobacter baumannii (Ab) is frequently observed in intensive care unit (ICU) patients but difficult to eliminate. Current clinical practice based on microbial population characterization and single-species-based antibiotic resistance profiling has ignored the potential interspecies interactions, which might lead to novel drug-resistance phenotypes. Here, we investigated the impacts of interspecies interactions on antibiotic therapies by establishing a Pa and Ab dual-species biofilm model. Our data showed that antibiotic exposure would reshape the community compositions of dual-species biofilms, and those of the extracellular polymeric substance (EPS) matrix of Pa, Psl exopolysaccharide in particular, promoted its interactions with Ab against imipenem stress. We further found other EPS structural fiber-eDNA contributed to the Psl-dependent dual-species biofilm stability under antibiotic treatment. Thus, targeting the EPS structural fibers such as Psl and extracellular DNA (eDNA) is a potent strategy for controlling polymicrobial biofilm related infections.
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