合成代谢
柠檬酸循环
分解代谢
三羧酸
代谢途径
生物化学
化学
细胞生物学
氨基酸
生物
新陈代谢
作者
Durga Mahor,Rishikesh Pandey,Vinay Bulusu
标识
DOI：10.1016/j.tibs.2022.03.006
摘要
Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox metabolic pathways.
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