Neurodegenerative disease: models, mechanisms, and a new hope

疾病 神经退行性变 神经科学 转化研究 数据科学 医学 生物 计算机科学 病理
作者
Aaron D. Gitler,Paraminder Dhillon,James Shorter
出处
期刊:Disease Models & Mechanisms [The Company of Biologists]
卷期号:10 (5): 499-502 被引量:565
标识
DOI:10.1242/dmm.030205
摘要

ABSTRACT Neurodegeneration is a feature of many debilitating, incurable diseases that are rapidly rising in prevalence, such as Parkinson's disease. There is an urgent need to develop new and more effective therapeutic strategies to combat these devastating diseases. Models – from cell-based systems, to unicellular organisms, to complex animals – have proven to be a useful tool to help the research community shed light on the mechanisms underlying neurodegenerative diseases, and these advances have now begun to provide promising therapeutic avenues. In this themed issue of Disease Models & Mechanisms, a special collection of articles focused on neurodegenerative diseases is introduced. The collection includes original research articles that provide new insights into the complex pathophysiology of such diseases, revealing candidate biomarkers or therapeutic targets. Some of the articles describe a new disease model that enables deeper exploration of key mechanisms. We also present a series of reviews that highlight some of the recent translational advances made in studies of neurodegenerative diseases. In this Editorial, we summarize the articles featured in this collection, emphasizing the impact that model-based studies have made in this exciting area of research.

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