生物碱
吲哚试验
吲哚生物碱
体外
细胞毒性
化学
立体化学
一氧化氮
传统医学
生物化学
有机化学
医学
作者
Leling Song,Yuguang Mu,Haochao Zhang,Guiying Wu,Jingyong Sun
标识
DOI:10.1080/14786419.2018.1536130
摘要
A new indole alkaloid, 17-oxo-19-(Z)-naucline, and six known alkaloids 2-7 were isolated from the branches of Nauclea officinalis. The structure of the new compound 1 was characterised mainly by analysing its physical data including IR, 1 D, 2 D NMR, and HR-ESI-MS. Other compounds were identified by comparisons their data with those reported in the literature. Compound1, 4, 5, 6, 7 showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitric oxide in RAW264.7 cell, while all compounds exhibited weak cytotoxicity against human tumour cell lines (LOVO, A549 and HepG2).
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