Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

These observations support local PD-(L)1 blockade to interrupt loco-regional immune suppression in CxCa and control metastatic spread to TDLN. Furthermore, our data identify CD8⁺FoxP3⁺CD25⁺ T cells as therapeutic targets, which may also serve as predictive biomarker for PD-(L)1 checkpoint blockade.