喹啉
奎宁
化学
抗真菌
组合化学
甲氟喹
催化作用
疟疾
药理学
恶性疟原虫
有机化学
医学
皮肤病科
免疫学
作者
Akhil Mahajan,Tejpal Singh Chundawat
出处
期刊:Mini-reviews in Organic Chemistry
[Bentham Science]
日期:2019-10-08
卷期号:16 (7): 631-652
被引量:7
标识
DOI:10.2174/1570193x15666181001142122
摘要
Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Quinine and Mefloquine which show Antimalarial activity. All the methodologies in last decade had been covered to provide a comprehensive review on the development of Quinoline analogs using metal catalyst. Since quinoline and its auxiliaries have extensive pharmacological activities and are moreover utilized as ligands in various metal complexes, various procedures have been now and again reported for their synthesis. We have tried here undertaking to collect a huge part of the procedure that has been represented in the written work by use of metal driving force. This review will be especially profitable to the examiner in quick exploring and developing another ecopleasing, capable and judicious protocol.
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