Graphical AbstractOpen in new tabDownload slidePersonalized GDMT through NT-proBNP monitoring. Patients whose NT-proBNP levels are elevated during the first week following discharge (>10%) may benefit from more intensive decongestion before advancing guideline-directed medical therapy (GDMT) up-titration (left). In contrast, patients with stable or decreasing NT-proBNP levels may benefit from early and aggressive up-titration of GDMT (right).