Protein glycosylation alterations in hepatocellular carcinoma: function and clinical implications

生物 糖基化 糖生物学 机制(生物学) 癌症研究 肝细胞癌 癌症 表观遗传学 生物信息学 免疫学 糖蛋白 遗传学 聚糖 基因 基因表达 哲学 DNA甲基化 认识论
作者
Yifei Wang,Huarong Chen
出处
期刊:Oncogene [Springer Nature]
卷期号:42 (24): 1970-1979 被引量:4
标识
DOI:10.1038/s41388-023-02702-w
摘要

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Understanding the cancer mechanisms provides novel diagnostic, prognostic, and therapeutic markers for the management of HCC disease. In addition to genomic and epigenomic regulation, post-translational modification exerts a profound influence on protein functions and plays a critical role in regulating various biological processes. Protein glycosylation is one of the most common and complex post-translational modifications of newly synthesized proteins and acts as an important regulatory mechanism that is implicated in fundamental molecular and cell biology processes. Recent studies in glycobiology suggest that aberrant protein glycosylation in hepatocytes contributes to the malignant transformation to HCC by modulating a wide range of pro-tumorigenic signaling pathways. The dysregulated protein glycosylation regulates cancer growth, metastasis, stemness, immune evasion, and therapy resistance, and is regarded as a hallmark of HCC. Changes in protein glycosylation could serve as potential diagnostic, prognostic, and therapeutic factors in HCC. In this review, we summarize the functional importance, molecular mechanism, and clinical application of protein glycosylation alterations in HCC.
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