碳水化合物代谢
脂质代谢
糖原
生物
碳水化合物
CD36
内科学
葡萄糖转运蛋白
内分泌学
糖原合酶
脂肪变性
新陈代谢
生物化学
胰岛素
受体
医学
作者
Liang Ji,Liulan Zhao,Chenxin Gong,Qiao Li,Yifan Hu,Hao Líu,Jiazhong Guo,Rui Huang,Zhiqiong Li,Song Yang
摘要
Yinchenhao decoction (YCHD) is a famous traditional Chinese medicine for improving hepatic metabolism disorder. The aim of this study was to investigate the effects of YCHD on lipid metabolism of juvenile largemouth bass fed on high-carbohydrate diet. Triplicate groups of fish (5.6 ± 0.2 g) were fed six experimental diets (one low-carbohydrate diet and five high-carbohydrate diets with gradients YCHD) for 10 weeks. The results showed that appropriate YCHD administration reversed the adverse effects of high-carbohydrate diet on the growth performance. Meanwhile, YCHD decreased the depositions of hepatic T-CHO, TG and NEFA, and alleviated lipids deposition in a dose-dependent manner. Importantly, as the key energy regulating element, AMPK was significantly increased by YCHD, coupled with high expression of β-oxidation (PPARα and CPT1) and lipids transport (APoB100, MTP, PNPLA7 CD36, CETP and FABP1) genes. Furthermore, PI3K-AKT pathway was prominently suppressed by YCHD, and the expression of lipids synthesis-related genes (ACCA, FAS and SCD1) was notably down-regulated. Additionally, YCHD up-regulated the expression of glycogen metabolism-related genes (GSK3β, PGY and GSY). In summary, our results demonstrated that YCHD promoted lipids β-oxidation and transport, enhanced glucose metabolism and reduced lipids deposition, indicating its beneficial effects on juvenile largemouth bass fed on high-carbohydrate diet.
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