匹罗卡品
法尼醇
药理学
化学
多巴胺
抗惊厥药
血清素
神经化学
毒蕈碱乙酰胆碱受体
抗焦虑药
多巴胺受体D2
内分泌学
内科学
癫痫
受体
医学
生物
神经科学
生物化学
作者
Gyllyandeson de Araújo Delmondes,Maria Janice Pereira Lopes,Isaac Moura Araújo,Alex de Sousa Borges,Paulo Ricardo Batista,Henrique Douglas Melo Coutinho,Irwin Rose Alencar de Menezes,José Maria Barbosa-Filho,Cícero Francisco Bezerra Felipe,Marta Regina Kerntopf
标识
DOI:10.1016/j.cbi.2022.110059
摘要
This study aimed to investigate, through in vivo and in vitro methodologies, the effect of acute trans,trans-farnesol (12.5, 25, 50 or 100 mg/kg, p.o.) administration on behavioral and neurochemical parameters associated with pilocarpine-induced epileptic seizure (300 mg/kg, i.p.) in mice. The initial results showed that the compound in question presents no anxiolytic-like or myorelaxant effects, despite reducing locomotor activity in the animals at all doses tested. In addition, the lowest dose increased the latency to onset of the first epileptic seizure, and the time to death. In addition to decreasing the mortality percentage in mice submitted to the pilocarpine model. In this same model, pretreatment with the lowest dose of the compound decreased the hippocampal concentrations of thiobarbituric acid and nitrite, and partially restored striatal concentrations of noradrenaline, dopamine, and serotonin. Taken together, the results suggest that trans,trans-farnesol presents a central depressant effect which contributes to its antiepileptic action which, in turn, seems to be mediated by the antagonism of muscarinic cholinergic receptors, reduction of oxidative stress. and modulation of noradrenaline, dopamine and serotonin concentrations in the central nervous system.
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