Advances in metal–organic frameworks for optically selective alkaline phosphatase activity monitoring: a perspective

The study of Metal-Organic Frameworks (MOFs) has gained significant momentum due to their remarkable properties, including adjustable pore sizes, extensive surface area, and customizable compositions, which have urged scientists to investigate their applicability in pertinent societal issues such as water absorption, environmental remediation, and sensor technology. MOFs have the ability to transport and detect specific biomolecules, including proteins. One such biomolecule is alkaline phosphatase (ALP) that can be influenced by various diseases and can lead to severe consequences when its regulation is disrupted. The porous nature of MOFs and their tunable nature allows them to selectively adsorb, interact directly or indirectly with ALP. This ultimately influences the electronic and optical properties of the MOF, leading to measurable changes. Early detection and continuous monitoring of ALP play a crucial role in the use of an effective treatment, and recent studies have shown that MOFs are effective in detecting alkaline phosphatases. This manuscript offers a thorough examination of the potential biomedical applications of MOFs for monitoring alkaline phosphatase and envisions possible future trends in this field.