糖尿病前期
丘脑
默认模式网络
医学
神经科学
静息状态功能磁共振成像
功能连接
大脑大小
认知
人口
2型糖尿病
糖尿病
心理学
磁共振成像
精神科
内分泌学
放射科
环境卫生
作者
Xin-Miao Zhang,Chang Liu,Wanlin Zhu,Yuesong Pan,Jiyang Jiang,Xueli Cai,Zhe Zhang,Zixiao Li,Yijun Zhou,Xia Meng,Jian Cheng,Yilong Wang,Hao Li,Yong Jiang,Huaguang Zheng,Suying Wang,Niu Huang,Wen Wang,Perminder S. Sachdev,Tiemin Wei,Tao Liu,Yongjun Wang
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2023-02-07
卷期号:46 (4): 819-827
被引量:2
摘要
OBJECTIVE To investigate the contribution of alterations in brain structure and function to cognitive function and their interactions in individuals with diabetes and patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS This population-based study included 2,483 participants who underwent structural MRI (n = 569 with normal glucose metabolism [NGM], n = 1,353 with prediabetes, and n = 561 with T2DM) and cognitive testing. Of these, 2145 participants also underwent functional MRI (n = 496 NGM, n = 1,170 prediabetes, and n = 479 T2DM). Multivariate linear regression models were used to assess the association of brain volume and functional connectivity with cognition, as well as the association of brain volume and functional connectivity. RESULTS Compared with NGM participants, those with T2DM had lower brain volume in a wide range of brain regions and stronger functional connectivity between the bilateral thalamus and brain functional network (visual network and default mode network), and those with prediabetes had lower brain volume in specific local regions (subcortical gray matter volume and subcortical subregions [bilateral thalamus, bilateral nucleus accumbens, and right putamen]) and stronger functional connectivity between the right thalamus and visual network. Cognition was associated with greater right thalamus volume and lower functional connectivity between the right thalamus and visual network. Functional connectivity between the right thalamus and visual network was associated with lower right thalamus volume. CONCLUSIONS Cognition was associated with greater brain volume and lower functional connectivity in T2DM. Increased functional connectivity may indicate a compensatory mechanism for reduced brain volume that begins in the prediabetic phase.
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