Evaluation of Anti Ulcer activity of Calycopteris floribunda Lams leaf extract in wistar rats

The present study provided preliminary data for the Calycopteris floribunda Lam. possess significant antiulcer activity in animal models. It has a gastric antisecretory and acid neutralizing effect that are comparable to standard drug Pantaprazole. The antiulcer activity is probably due to the presence of bioactive compounds like Flavonoids, Tannins. These compounds protect and strengthen the mucosal barrier which may be responsible for the antiulcer activity. The Statistical study shows C. floribunda extract treatment showed decrease in the acid volume of the gastric secretion and SGOT and SGPT levels are decreased in C. floribunda extract treated groups. Calycopteris floribunda Lam treatment showed increase in the glutathione content. The outcome of the study provides anti ulcer activity against ethanol induced gastric ulcer, Cold water immersion induced stress ulcer, Immobilization induced stress ulcer.