超分子化学
癌症化疗
纳米技术
超分子组装
材料科学
分子
癌症
化学
医学
内科学
有机化学
作者
M. T. Jeena,Seongeon Jin,Ki‐Hun Jeong,Yuri Cho,Jin Chul Kim,Ju Han Lee,Seokyoung Lee,Suk Won Hwang,Sang Kyu Kwak,Sehoon Kim,Ja‐Hyoung Ryu
标识
DOI:10.1002/adfm.202208098
摘要
Intramitochondrial supramolecular assembly can be a new therapeutic strategy for treating cancer because mitochondria are the key for virtually all facets of the tumorigenesis. However, the in vivo applications of mitochondria-targeting molecules are limited due to the positive charge and hydrophobicity that should be possessed by these molecules to penetrate the mitochondrial membrane, which may induce nonspecific serum protein interactions and normal cell accumulation. Herein, a stimuli-responsive mitochondria-targeting molecule, Mito-SA that forms nano-sized micelles under physiological conditions is presented. In the aggregated state, the succinic amide bonds in Mito-SA are cleaved in response to tumoral pH by stabilizing the transition state through the intermolecular interactions and the micelle disassembles into a mitochondria-targeting parent molecule, Mito-FF. The Mito-FF accumulate inside cancer mitochondria to induce cell death by intra-mitochondrial self-assembly into fiber structures. This tumoral stimuli-responsive disassembly–assembly approach will provide insight to develop mitochondria targeted supramolecular anticancer agent with high tumoral specificity.
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