免疫系统
神经科学
肠道菌群
肠-脑轴
肠神经系统
平衡
免疫学
抗生素
生物
微生物学
细胞生物学
作者
Ellen Merrick Schill,Alexandria N. Floyd,Rodney D. Newberry
标识
DOI:10.1016/j.tins.2022.10.002
摘要
Interactions between the enteric nervous system (ENS), immune system, and gut microbiota regulate intestinal homeostasis in adults, but their development and role(s) in early life are relatively underexplored. In early life, these interactions are dynamic, because the mucosal immune system, microbiota, and the ENS are developing and influencing each other. Moreover, disrupting gut microbiota and gut immune system development, and potentially ENS development, by early-life antibiotic exposure increases the risk of diseases affecting the gut. Here, we review the development of the ENS and immune/epithelial cells, and identify potential critical periods for their interactions and development. We also highlight knowledge gaps that, when addressed, may help promote intestinal homeostasis, including in the settings of early-life antibiotic exposure.
科研通智能强力驱动
Strongly Powered by AbleSci AI