间充质干细胞
良好制造规范
再生医学
生物反应器
移植
组织工程
干细胞
离体
生物医学工程
生化工程
生物技术
医学
体内
细胞生物学
生物
工程类
病理
外科
监管事务
植物
作者
Marina Gazdic,Miodrag Stojković,Sanja Bojić,Nemanja Jovičić,Marina Miletić Kovačević,Zeljko Ivosevic,Aleksandar Juskovic,Vojin Kovačević,Biljana Ljujić
标识
DOI:10.1016/j.retram.2023.103393
摘要
Human mesenchymal stem cells (hMSCs) are multipotent cells and an attractive therapeutic agent in regenerative medicine and intensive clinical research. Despite the great potential, the limitation that needs to be overcome is the necessity of ex vivo expansion because of insufficient number of hMSCs presented within adult organs and the high doses required for a transplantation. As a result, numerous research studies aim to provide novel expansion methods in order to achieve appropriate numbers of cells with preserved therapeutic quality. Bioreactor-based cell expansion provide high-level production of hMSCs in accordance with good manufacturing practice (GMP) and quality standards. This review summarizes current knowledge about the hMSCs manufacturing platforms with a main focus to the application of bioreactors for large-scale production of GMP-grade hMSCs.
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