伤口愈合
材料科学
自愈
伤口敷料
生物医学工程
自愈水凝胶
纳米技术
复合材料
高分子化学
医学
外科
病理
替代医学
作者
Guofeng Zhong,Pingchong Lei,Ping Guo,Yang Qin,Yun Duan,Junbo Zhang,Mengyu Qiu,Kaijun Gou,Chen Zhang,Yan Qu,Rui Zeng
出处
期刊:Small
[Wiley]
日期:2024-03-10
标识
DOI:10.1002/smll.202309568
摘要
Wounds in harsh environments can face long-term inflammation and persistent infection, which can slow healing. Wound spray is a product that can be rapidly applied to large and irregularly dynamic wounds, and can quickly form a protective film in situ to inhibit external environmental infection. In this study, a biodegradable A and B combined multi-functional spray hydrogel is developed with methacrylate-modified chitosan (CSMA1st ) and ferulic acid (FA) as type A raw materials and oxidized Bletilla striata polysaccharide (OBSP) as type B raw materials. The precursor CSMA1st -FA/OBSP (CSOB-FA1st ) hydrogel is formed by the self-cross-linking of dynamic Schiff base bonds, the CSMA-FA/OBSP (CSOB-FA) hydrogel is formed quickly after UV-vis light, so that the hydrogel fits with the wound. Rapid spraying and curing provide sufficient flexibility and rapidity for wounds and the hydrogel has good injectability, adhesive, and mechanical strength. In rats and miniature pigs, the A and B combined spray hydrogel can shrink wounds and promote healing of infected wounds, and promote the enrichment of fibrocyte populations. Therefore, the multifunctional spray hydrogel combined with A and B can protect irregular dynamic wounds, prevent wound infection and secondary injury, and be used for safe and effective wound treatment, which has a good prospect for development.
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