Pulsed Magnetic Field Generator for Enhancing Cell Membrane Permeability In Vitro

The noncontact pulsed magnetic field (PMF) treatment can enhance cell membrane permeability, but its efficiency is relatively low. To enhance its efficiency, this article has developed a more optimized PMF generator: this generator can produce a maximum magnetic induction intensity of 1.9 T; and a maximum-induced electric field of approximately 110 V/cm with a uniformity of up to 84%. Importantly, the generator developed in this article can also generate a higher spatial gradient of the magnetic field, approximately 1000 T/m, a capability that was previously lacking in research. Subsequently, by customizing the coil structure and the heat dissipation system, we ensured both temperature control of the treatment plane and a sufficiently large effective treatment volume. Finally, the effectiveness of the PMF generator was confirmed through in vitro cell experiments.