医学
感音神经性聋
脑膜炎
脑脊液
猪链球菌
听力损失
内科学
肺炎链球菌
改良兰金量表
儿科
抗生素
听力学
生物化学
化学
缺血性中风
缺血
毒力
生物
微生物学
基因
作者
Shan Deng,Baoquan Lin,Baohui Weng,Hong Yang,Kejian Zhou,Liya Wu,Lu Qin,Liya Pan
出处
期刊:American Journal of Tropical Medicine and Hygiene
[American Society of Tropical Medicine and Hygiene]
日期:2023-01-23
标识
DOI:10.4269/ajtmh.22-0515
摘要
We analyzed the clinical characteristics and outcomes of patients with Streptococcus suis meningitis in Liuzhou, China, to improve diagnostic accuracy and lower the chances of misdiagnosis. The major clinical manifestations, auxiliary examination results, treatment strategies, treatment efficacy, and follow-up results of 17 consecutively admitted patients with S. suis meningitis were evaluated. The most common clinical manifestations were fever (15/17), sensorineural hearing loss (13/17), headache (11/17), and altered mental status (8/17). In addition, 64.71% of the patients had residual symptoms of sensorineural hearing loss at discharge, and moderate disabilities occurred in 68.75% of the patients in the form of sensorineural deafness (11/17) and hemiparesis (1/17). The cerebrospinal fluid (CSF) of nine patients was used for metagenomic analysis with next-generation sequencing. The metagenomic analysis of CSF of four patients was positive, whereas blood and CSF cultures were negative. The average modified Rankin Scale (mRS) and Activities of Daily Living (ADL) scores improved significantly at the 6-month follow-up compared with those at admission ( P < 0.05). There was no correlation between altered mRS and ADL scores and the CSF findings ( P > 0.05). Early administration of antibiotics can prevent sensorineural hearing loss. Early CSF metagenomic analysis may be superior to blood and CSF culture.
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