Interfaces Between Nanoparticle and Biomacromolecular Network: Dynamic Behaviors, Confinement and Entropy

Abstract Biomacromolecular networks, crucial components of biological systems, are of great importance in biological and nanomedical science, in which the interfaces between nanoparticle and macromolecular networks are intriguing and drawing great attention. Herein, this review seeks to present the state‐of‐art progress and perspective of the dynamic behaviors, confinement and entropy at the nanoparticle‐biomacromolecular network interfaces. The basic biomacromolecular networks in living systems, recent research on networks with dynamic bonds and various diffusion behaviors of nanoparticles within biomacromolecular networks are summarized. In particular, entropic effects in the confined environments of biological networks are discussed, along with how they impact the mechanical properties and dynamical behaviors. The interesting research and findings included in this review might offer the scientific community a better understanding of how this field has developed thus far, and are anticipated to trigger more systematic and fundamental research to elucidate the underlying physics and broaden the potential applications of macromolecular networks, biological and artificial.