Molecular Chirality of Biosynthesized PHB Translates into Uniformly Curved Single Crystals in Langmuir Films

Abstract While in nature, molecular chirality enables the formation of chiral macroscopic structures through crystallization and self‐organization, such a transfer of molecular information to higher hierarchical levels is rarely observed in vitro. Here, the study reports on single crystals of microbially synthesized polyester poly[(R)‐3‐hydroxybutyrate], which have chiral habits when grown at the air–water interface, in analogy to the 2D crystallization of chiral lipids such as DPPC. Depending on the crystallization conditions, the chiral single crystals either undergo a transition into fiber‐like structures, orassemble into larger superstructures with a uniform sense of rotation.