化学
炔烃
瞬态(计算机编程)
组合化学
立体化学
药物化学
有机化学
催化作用
程序设计语言
计算机科学
作者
Jianguo He,Tongxiang Cao,Kai Chen,Shifa Zhu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-03-27
卷期号:26 (13): 2596-2600
标识
DOI:10.1021/acs.orglett.4c00608
摘要
Carboacylation of an unsaturated bond represents a powerful transformation. However, only a few examples of carboacylation of alkyne have been reported through C-C bond scission and reconnection. Here, we report a method of carboacylation of an unactivated alkyne by utilizing nonstrained C-C bonds under gold(I) catalysis. The density functional theory computational and experimental studies reveal that the reaction proceeds through a C-to-C formal 1,3-acyl migration via a solvent cage-nested acylium cation.
科研通智能强力驱动
Strongly Powered by AbleSci AI