胰岛素抵抗
蛋白激酶B
汤剂
葡萄糖摄取
链脲佐菌素
胰岛素
化学
葡萄糖转运蛋白
药理学
腓肠肌
2型糖尿病
糖尿病
2型糖尿病
内分泌学
传统医学
内科学
医学
生物化学
细胞凋亡
骨骼肌
作者
P. Gasparini,Ingrid Candido Garofolo,Monica Marques Telles,Lila Missae Oyama,Viviane de Mello Veneza,Thiago André Moura Veiga,Vera Lucia Flor Silveira,Luciana C. Caperuto
标识
DOI:10.1080/14786419.2022.2113875
摘要
Bioactive metabolites from Bauhinia forficata Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM in vivo. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the gastrocnemius muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance.
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