Superoxide Dismutase (SOD): A Promising Enzyme in the Area of Biopharmaceuticals in Its Native and Immobilized Form: A Review

Abstract: Super Oxide Dismutase (SOD) an ubiquitous potent antioxidant enzyme primarily scavenges reactive oxygen species (ROS) like superoxide radicals, which causes oxidative damage to a living organism’s essential proteins, lipids and its DNA. The accumulation of ROS in the body is a major inductive factor aging related diseases. It is important to maintain ROS at an appropriate level to prevent these diseases. SOD is a vital enzyme in defending against oxidative damage in vivo. The SOD enzyme promises to be a good therapeutic agent against ROS. The present review describes the therapeutic effects of SOD in some physiological and pathological conditions. Because of the defects in the direct application of SOD or SOD mimics, different mounting delivery systems (immobilization enzyme systems) have been developed for the efficient applications of SOD to realize antioxidant treatment.