光热治疗
石墨烯
材料科学
光动力疗法
纳米颗粒
阿霉素
纳米技术
介孔二氧化硅
氧化物
赫拉
纳米医学
介孔材料
化学
细胞
有机化学
医学
催化作用
化疗
生物化学
外科
冶金
作者
Chenguang Zhang,Yuting Cai,Pengrui Dang,Jiechen Wang,Lu Wang,Jinkai Xu,Yuxin Wu,Wenwen Liu,Lili Chen,Zhengtang Luo,Feilong Deng
摘要
Abstract Developing a nanosystem that can perform multimodal imaging‐guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide‐grafted hollow mesoporous organosilica loaded with the drug doxorubicin (DOX) and photosensitizers tetraphenylporphyrin (TPP). These NPs were encapsulated by thermosensitive liposomes that release their contents once the temperature exceeds a certain threshold. Metal oxide NPs grown on the graphene oxide (GO) surface served multiple roles, including enhancing photothermal efficiency, acting as contrast agents to improve magnetic resonance imaging, increasing the sensitivity and specificity of photoacoustic imaging, and catalysing hydrogen peroxide for the generation of reactive oxygen species (ROS). When locally injected, the HMONs‐rNGO@Fe 3 O 4 /MnOx@FA/DOX/TPP NPs effectively enriched in subcutaneous Hela cell tumour of mice. The photothermal/photodynamic/chemo combination therapy triggered by near‐infrared (NIR) successfully suppressed the tumour without noticeable side effects. This study presented a unique approach to develop multimodal imaging‐guided combination therapy for cancer.
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