声动力疗法
胶质瘤
医学
光敏剂
超声波
光动力疗法
病理
外科
放射科
癌症研究
化学
有机化学
作者
Takafumi Ohmura,Takeo Fukushima,Hirotomo Shibaguchi,Shin Yoshizawa,Takeshi Inoue,Masahide Kuroki,Kazunari Sasaki,Shin Ichiro Umemura
出处
期刊:PubMed
日期:2011-07-01
卷期号:31 (7): 2527-33
被引量:30
摘要
5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer. In this study, sonodynamically induced selective antitumour effect of 5-ALA for deep-seated lesions was evaluated.First, normal rat brains were sonicated via a transducer placed on the dural surface to confirm safe acoustic conditions for normal rat brains. One week after inoculation of brains with C6 rat glioma cells, brains with/without administration of 5-ALA (100 mg/kg body weight) were sonicated.Sonodynamic therapy (SDT) with 5-ALA and focused ultrasound (10 W/cm(2), 1.04 MHz, 5 min) achieved selective antitumour effect against deep-seated experimental glioma. Mean tumour sizes in the largest coronal section in sham-operated rats and rats receiving ultrasound with/without 5-ALA were 29.94±10.39, 18.32±5.69 and 30.81±9.65 mm(2), respectively. Tumour size was significantly smaller in the SDT group than in other groups (p<0.05).This experimental rat model showed that SDT appears to be useful in the treatment of deep-seated malignant glioma.
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