多囊卵巢
胰岛素抵抗
内分泌学
内科学
胰岛素
基因座(遗传学)
生物
胰岛素受体
等位基因
代谢综合征
2型糖尿病
2型糖尿病
遗传连锁
糖尿病
医学
遗传学
基因
作者
Susan Sam,Andrea Dunaif
标识
DOI:10.1016/j.tem.2003.08.002
摘要
Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic and reproductive disorder. It is associated with substantial defects in insulin action and secretion that confer a markedly increased risk for type 2 diabetes mellitus. Insulin resistance modifies reproductive function both by the direct actions of insulin on steroidogenesis and by disruption of insulin signaling pathways in the central nervous system. These insights have led to a new therapy for PCOS with insulin-sensitizing agents. Hyperandrogenemia and insulin resistance cluster in PCOS families, consistent with a genetic susceptibility to these abnormalities. There is evidence for both linkage and association of the hyperandrogenemia phenotype with an allele of a marker locus on chromosome 19, in the region of the gene encoding the insulin receptor.
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