毒扁豆碱
东莨菪碱
胆碱能的
助记符
心理学
识别记忆
氢溴酸东莨菪碱
备忘录
副交感神经溶解性
失忆症
神经科学
会话(web分析)
麻醉
毒蕈碱乙酰胆碱受体
医学
认知心理学
认知
内科学
计算机科学
万维网
受体
作者
Thomas Aigner,Mortimer Mishkin
出处
期刊:Behavioral and Neural Biology
[Elsevier]
日期:1986-01-01
卷期号:45 (1): 81-87
被引量:213
标识
DOI:10.1016/s0163-1047(86)80008-5
摘要
The visual recognition of rhesus monkeys was evaluated by means of a delayed nonmatching-to-sample task with trial-unique objects. Each daily session consisted of two lists of 20 objects each, which untreated animals were able to recognize at approximately 75% accuracy. When they were performing at this level reliably, doses of physostigmine (0.32, 1.0, 3.2, 10.0, 32.0, 56.0 μg/kg), scopolamine (1.0, 3.2, 5.6, 10.0, 17.8, 32.0 μg/kg), or saline were administered 20 min prior to the session. Physostigmine and scopolamine produced dose-related increases and decreases, respectively, in the number of objects correctly remembered. The systematic changes in performance support the view that cholinergic mechanisms contribute to recognition memory and suggest that tasks with trial-unique objects may be particularly useful for studying the mnemonic effects of cholinergic drugs.
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