他克莫司
医学
造血干细胞移植
移植物抗宿主病
移植
临床试验
并发症
疾病
干细胞
钙调神经磷酸酶
免疫学
内科学
生物
遗传学
作者
Kara Fortune,Daniel R. Couriel
标识
DOI:10.1517/17425250903044959
摘要
Background: Graft-versus-host disease (GVHD) associated with allogeneic peripheral blood or marrow transplantation is a serious life-threatening complication. Most of the available literature support the use of tacrolimus as a prophylactic agent for acute GVHD. Objective: To review the pharmacology, efficacy and safety of tacrolimus and recommend its place in therapy for the prophylaxis of GVHD. Methods: We conducted a literature search using PubMed/Medline (January 1996 – December 2008) using the keywords tacrolimus, graft-versus-host disease and hematopoietic stem cell transplantation. Data provided by the manufacturer and the FDA were also reviewed. Conclusion: Tacrolimus is effective in the prevention of acute GVHD. Trials comparing tacrolimus with cyclosporine using tacrolimus levels in the 7 – 10 ng/ml range and with larger numbers of patients may be necessary to better understand the impact of these drugs on survival.
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