亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Human Epidermal Growth Factor Receptor Type 2-Positive Breast Cancer: Association of MRI and Clinicopathologic Features With Tumor-Infiltrating Lymphocytes

医学 乳腺癌 病理 肿瘤浸润淋巴细胞 肿瘤科 内科学 免疫组织化学 表皮生长因子受体 癌症研究 人表皮生长因子受体2 癌症 雌激素受体 受体
作者
Hyo-Jae Lee,Jong Eun Lee,Won Gi Jeong,So Yeon Ki,Min Ho Park,Ji Shin Lee,Yoo Kyeong Nah,Hyo Soon Lim
出处
期刊:American Journal of Roentgenology [American Roentgen Ray Society]
标识
DOI:10.2214/ajr.21.26400
摘要

Background: Tumor-infiltrating lymphocytes (TILs) are associated with therapeutic outcomes and prognosis in patients with human epidermal growth factor receptor type 2-positive (HER2+) breast cancer. Identification of TIL levels is clinically relevant. Objective: To explore associations of clinicopathologic and MRI features with TIL levels in patients with HER2+ breast cancer. Methods: A total of 212 consecutive women (mean age, 54 years) diagnosed with HER2+ breast cancer between January 2017 and December 2019 were included in this retrospective study. Patients were divided into low (<10%) and high (≥10%) TIL groups. Three breast radiologists independently reviewed images; interreader agreement was assessed, and the first readers' findings were used for further analysis. Associations of clinicopathologic and MRI features with TIL levels were evaluated using multivariable logistic regression analysis. Subanalysis of TIL levels by hormone receptor (HR) status was also performed. Results: A total of 115 (54.2%) patients had low, and 97 (45.8%) had high, TIL levels. High TIL level was associated (all p<.05) with histologic grade 3 (odds ratio [OR]=3.98; frequency of 78.4% vs 52.2% in high vs low TIL groups, respectively), high tumor cellularity (OR=4.59; median cellularity of 60% vs 50%), lower frequency of associated ductal carcinoma in situ (OR=0.16; frequency of 86.6% vs 94.8%), and higher frequency of peritumoral edema on T2-weighted images (OR=2.83; 71.1% vs 50.4%). In subgroup analysis by HR status, histologic grade 3 (OR=5.03, p=.002) was a significant independent predictor of high TIL in the HR+/HER2+ group, while high tumor cellularity (OR=9.06, p=.002), peritumoral edema (OR=5.23, p=.03), and low ADC (OR=11.69, p=.047) were independent predictors of high TIL in the HR-/HER2+ group. Interreader agreement for peritumoral edema was moderate among the three radiologists (к, range 0.432-0.539). Conclusion: Peritumoral edema on MRI and histopathologic feature of tumor aggressiveness help predict high TIL levels in patients with HER2+ breast cancer. Clinical Impact: Pretreatment MRI features may serve as a useful tool for assessing TIL levels in patients with HER2+ breast cancer, helping to classify patients with variable clinical outcomes related to immune activity and to guide selection among neoadjuvant chemotherapy (NAC) or HER2-targeted therapy or immunotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
4秒前
Mike001发布了新的文献求助30
9秒前
所所应助科研通管家采纳,获得10
15秒前
Willing完成签到,获得积分10
26秒前
maher完成签到,获得积分10
39秒前
曾先生完成签到,获得积分10
44秒前
57秒前
1分钟前
1分钟前
2023完成签到,获得积分10
1分钟前
勤奋初之完成签到 ,获得积分10
1分钟前
SOLOMON应助科研通管家采纳,获得30
2分钟前
wyh295352318完成签到 ,获得积分10
2分钟前
我是老大应助ANEWKID采纳,获得10
2分钟前
2分钟前
ANEWKID发布了新的文献求助10
2分钟前
积木完成签到 ,获得积分10
2分钟前
3分钟前
3分钟前
水牛发布了新的文献求助10
3分钟前
李健的小迷弟应助ANEWKID采纳,获得10
3分钟前
科研通AI2S应助水牛采纳,获得10
3分钟前
mellow完成签到,获得积分10
3分钟前
3分钟前
赘婿应助仔wang采纳,获得10
3分钟前
白酒RH发布了新的文献求助10
3分钟前
3分钟前
仔wang发布了新的文献求助10
4分钟前
仔wang完成签到,获得积分10
4分钟前
感动白开水完成签到,获得积分10
4分钟前
把门开开儿完成签到 ,获得积分10
4分钟前
王衡完成签到 ,获得积分10
5分钟前
SOLOMON应助科研通管家采纳,获得10
6分钟前
6分钟前
d.zhang完成签到,获得积分10
6分钟前
6分钟前
ANEWKID发布了新的文献求助10
6分钟前
青春梦完成签到 ,获得积分10
7分钟前
白酒RH完成签到 ,获得积分10
7分钟前
杭采蓝完成签到 ,获得积分10
7分钟前
高分求助中
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Sport in der Antike 800
De arte gymnastica. The art of gymnastics 600
Berns Ziesemer - Maos deutscher Topagent: Wie China die Bundesrepublik eroberte 500
Stephen R. Mackinnon - Chen Hansheng: China’s Last Romantic Revolutionary (2023) 500
Sport in der Antike Hardcover – March 1, 2015 500
Psychological Warfare Operations at Lower Echelons in the Eighth Army, July 1952 – July 1953 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2424641
求助须知:如何正确求助?哪些是违规求助? 2112373
关于积分的说明 5350349
捐赠科研通 1839964
什么是DOI,文献DOI怎么找? 915890
版权声明 561327
科研通“疑难数据库(出版商)”最低求助积分说明 489899