[Antigenic evolution of influenza virus and the implications for influenza vaccine development].

Influenza virus has a continuous and extensive impact on human health around the world. Its extensive animal host characteristics and highly variable characteristics lead to continuous antigen drift and change of susceptible populations, causing repeated global influenza epidemics, and also affecting the protective effect of seasonal influenza vaccine. This research in a number of subtypes of influenza a virus, for example, from the antigenic drift of antigenicity, influence of the seasonal influenza vaccine strains and popular strain compatibility, broad-spectrum flu vaccine development train of thought, etc. summarizes the progress of relevant research, to deepen the understanding of the influenza virus antigenic evolution, provide reference for flu vaccine development in the future.流感病毒持续而广泛地影响全球人类健康，其广泛的动物宿主特性、高度变异的特点导致抗原不断漂移，易感人群更迭，引起全球流感流行反复发生，也影响着季节性流感疫苗的保护效果。本研究以多种亚型的甲型流感病毒为例，从抗原性漂移对抗原性的影响、季节性流感疫苗株与流行株的匹配度、广谱流感疫苗研发的思路等方面，对相关的研究进展作一综述，以加深对流感病毒抗原性进化的理解，为流感疫苗未来研发思路提供参考。.