微生物群
失调
癌症
液体活检
癌变
前列腺癌
癌症生物标志物
免疫系统
癌症免疫疗法
免疫学
DNA损伤
癌症研究
生物标志物
免疫疗法
人体微生物群
生物
计算生物学
DNA
生物信息学
遗传学
作者
Haiming Chen,Yi Ma,Zheng Liu,Jiawei Li,Xiao Li,Fan Yang,Mantang Qiu
标识
DOI:10.1016/j.canlet.2021.08.036
摘要
Dysbiosis of the human microbiome has long been reported to be closely associated with various cancers. Accumulating studies have shown that microbial dysbiosis can accelerate tumorigenesis through tumor-promoting inflammation, DNA damage, and inducing immune evasion. Differential composition of microbiome could be novel biomarkers for cancer detection or biomarkers of successful immunotherapy. More importantly, emerging evidence demonstrates that alterations of circulating microbiome DNA (cmDNA) could serve as promising noninvasive biomarkers for cancer detection. It has been reported that distinct circulating bacterial DNA could distinguish prostate cancer, lung cancer, and melanoma patients from healthy populations. Therefore, in this review, we summarized current literature on microbial biomarkers for cancer detection and unraveled the potential of cmDNA as a promising cancer detection tool.
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