溶解度
细胞毒性
HEK 293细胞
化学
溶解
体外
A549电池
白藜芦醇
细胞培养
MTT法
核化学
生物化学
有机化学
受体
生物
遗传学
作者
Yijie Lou,Kaxi Yu,Xiajun Wu,Zhaojun Wang,Yusheng Cui,Hanxiao Bao,Jianwei Wang,Xiurong Hu,Yunxi Ji,Guping Tang
出处
期刊:Molecules
[MDPI AG]
日期:2021-09-21
卷期号:26 (18): 5722-5722
被引量:5
标识
DOI:10.3390/molecules26185722
摘要
Resveratrol (RSV) and polydatin (PD) have been widely used to treat several chronic diseases, such as atherosclerosis, pulmonary fibrosis, and diabetes, among several others. However, their low solubility hinders their further applications. In this work, we show that the solubility of PD can be boosted via its co-crystallization with L-proline (L-Pro). Two different phases of co-crystals, namely the RSV-L-Pro (RSV:L-Pro = 1:2) and PD-L-Pro (PD:L-Pro = 1: 3), have been prepared and characterized. As compared to the pristine RSV and PD, the solubility and dissolution rates of PD-L-Pro in water (pH 7.0) exhibited a 15.8% increase, whereas those of RSV-L-Pro exhibited a 13.8% decrease. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay of pristine RSV, PD, RSV-L-Pro, and PD-L-Pro against lung cancer cell line A549 and human embryonic kidney cell line HEK-293 indicated that both compounds showed obvious cytotoxicity against A549, but significantly reduced cytotoxicity against HEK-293, with PD/PD-L-Pro further exhibiting better biological safety than that of RSV/RSV-L-Pro. This work demonstrated that the readily available and biocompatible L-Pro can be a promising adjuvant to optimize the physical and chemical properties of RSV and PD to improve their pharmacokinetics.
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