伤口愈合
再生(生物学)
医学
细胞外小泡
皮肤修复
组织修复
炎症
干细胞
细胞生物学
生物信息学
免疫学
生物
生物医学工程
作者
Deimantė Narauskaitė,Gabrielė Vydmantaitė,Justina Rusteikaitė,Revathi Sampath,Akvilė Rudaitytė,Gabija Stašytė,María Isabel Aparicio Calvente,Aistė Jekabsone
摘要
Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.
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